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专利名称：MAMMALIAN RELAXIN RECEPTORS发明人：Sheau Yu Hsu,Aaron J.W. Hsueh申请号：US12426771申请日：20090420
公开号：US20090298770A1公开日：20091203
摘要：High affinity relaxin receptors, polypeptide compositions related thereto, aswell as nucleotide compositions encoding the same, are provided. These proteins, hereintermed LGR7 and LGR8, are orphan leucine-repeat-containing, G protein-coupledreceptors. These receptors have a wide and a unique tissue expression pattern. Thereceptors, particularly soluble fragments thereof, are useful as therapeutic agentscapable of inhibiting the action of relaxin and InsL3. The receptors and fragments thereofalso find use in the screening and design of relaxin agonists and antagonists. Conditionstreatable with relaxin agonists or antagonists include prevention or induction of labor,treatment of endometriosis, treatment of skin conditions such as scleroderma thatrequire collagen or extracellular matrix remodelling. Additionally, relaxin has beenimplicated in the dilation of blood vessels' smooth muscle cells directly and throughrelease of nitric oxide and atrial natriuretic peptide. Relaxin has also been used in thetreatment of severe chronic pain, particularly pain arising from stretching, swelling, ordislocation of tissues.
申请人：Sheau Yu Hsu,Aaron J.W. Hsueh
地址：Menlo Park CA US,Stanford CA US
国籍：US,US
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