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专利名称：PROCESS FOR THE MANUFACTURE OF (S)-3-AMINO-1-SUBSTITUTED-PYRROLIDINES
发明人：LE, Tung, Van,SPENCE, F., Gregory,WEMPLE,
James, Norton
申请号：EP93912301.4申请日：19930416公开号：EP0638068B1公开日：19990623
摘要：A novel process for preparing a stereospecific (S)-3-amino-1-substitutedpyrrolidine used as a key intermediate in preparing quinolone and naphthyridoneantibacterial agents where the 7-position is occupied with a stereospecific 3-amino-pyrrolidine side chain is described starting from inexpensive L-aspartic acid. L-aspartic acidis converted to the desired (S)-3-aminopyrrolidine via a novel, high yield transformation ofa substituted aziridine.
申请人：WARNER LAMBERT CO
地址：US
国籍：US
代理机构：Mansmann, Ivo
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